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Differential bio's virtual bioprocess simulator, Arsenale Bioyards' PICCOLO bioreactors patent, Novo Nordisk’s SIBR CRISPR toolkit, Isomorphic labs' raise, Indigenous Bioeconomy, Nucleate AI hackathon

Differential Bio out of stealth with $2.2 million pre-seed

Enter the virtual bioprocess simulator: you adjust different cultivation parameters for your strain of interest, get accurate predictions for your key performance indicators and select the best optimization parameters. In just 4 weeks, before you waste any unnecessary wetlab bucks and time, Differential has helped you reduce your bioprocess costs by up to 3x and increase titer by up to 80%.

You can either use your own wetlab, or seamlessly gather experimental data through their self-driving lab with full IP protection to optimize parameters in your media, strain selection, cell metabolism, post-freezing survival, and shelf stability of your end product.

Image by Differential Bio

Arsenale Bioyards raises €9.5 million

Their precision fermentation platform uses a bench-scale high system of ‘Piccolo’ bioreactors to conduct high throughput experiments. They translate these results into industrial (*10^6) scale to make predictions using AI, and finally test out performance in their 6 x 50,000 L bioreactors yard.

PICCOLO comprises a sensor suite (121, 123) that autonomously move across the arrays to perform real-time, in situ measurements without manual intervention or external plate readers. Its five-bottle system (105) controls gas, waste, auxiliary reagents, media, and seed cultures, automating feeding, sampling, and waste removal without external robotic arms.

Piccolo and an individual PCB