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Mitotherapies, GLP-1 as a band-aid, Doudna's mini CRISPR for plants, plant-based vaginal optimization, and Sperm racing marks the beginning of bioSports

Mitotherapies!

How often do you think of the mitochondrial empire? Did you know that aerobic exercise promotes mitochondrial replication? My bestie David Friedberg, also told me mitochondria can be transferred from one cell to another through transient cellular connections, extracellular vesicles, or releasing them to outer (extracellular) space for capture. Apparently, this process is involved in cancer, wound healing, cartilage regeneration, memory loss, and many other conditions, which means… mitochondria could become our new medicine?!

Akin to how insulin supply once depended on pigs, mitochondrial transplantation used to be limited by the availability of healthy mitochondria (10⁹ mitochondria injection/patient) in human liver and muscle tissues. Instead, Chinese researchers just managed to use mesenchymal stem cells (MSCs) as mitochondria factories. Their innovation lies in an optimized culture medium that honed in a balance between cell proliferation and mitobiogenesis, resulting in a 854x increase in mitochondria production and a 5.7x increase in ATP production within 15 days.

You should care because mitotherapy can significantly regenerate osteoarthritic mice in 12 weeks. Also, because in epithelial wounds, platelet mitochondria are released in the extracellular space and bind to the surface of neutrophils, driving an antimicrobial inflammatory response. Want more? Cancer cells obtain mitochondria from T cells and macrophages, impairing antitumor immunity and driving cancer cells proliferation. MSCs also transfer mitochondria to T cells, inhibiting inflammatory cytokine production, limiting joint damage in arthritis.

GLP-1 as a band-aid